Telomerase Background
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Telomere's in red at end of chromosomes |
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The HeLa cell line was derived for use in cancer research. These cells proliferate abnormally rapidly, even compared to other cancer cells. Like many other cancer cells, HeLa cells have an active version of telomerase during cell division, which prevents the incremental shortening of telomeres that is implicated in aging and eventual cell death. In this way the cells circumvent the Hayflick Limit, which is the limited number of cell divisions that most normal cells can later undergo before becoming
senescent(cell death).
Current Research
The journal
Nature published a fascinating study about the enzyme’s effect on genetically engineered mice last year. In the study, researchers bred mice that, in normal conditions,
didn’t create telomerase. The mice grew to adulthood without the enzyme.
Then, for a month, the team provided the mice with a trigger chemical
that allowed the mice to create telomerase.
Without the telomerase, the researchers discovered that the mice tend
to age prematurely. They contracted osteoporosis or diabetes, and they
tended to die earlier than normal mice. Then, during their month with
telomerase, things turned around.
Sterile animals became fertile again. Prematurely aged internal
organs returned to health. Telomerase also reversed aging’s effects in
the mouse’s brains.
Other cutting edge research on telomerase shown to extend telomeres length longer than usual
Products On the Market Now
1.TA sciences and ta-65 telomerase shortening supplements
October 2010, Intertek/AAC Labs, an ISO 17025 internationally recognized
lab, found the largest component of TA-65 to be Cycloastragenol
600$ per 3 months supply at TA Sciences
2.Alternative that may work is Cycloastragenol supplements 1-2months supply for 300$
3.Astragulus directly from the root where the ta-65 extract came from. If you go this route be careful as Astragulus root has been shown to suppress the immune system or even be toxic in some species of this plant.
Warnings
Some precautions before trying these supplements. Since this is new research there is always the possibility of unknown side effects over longer term usage. Telomerase is produced in cancer cells so it is possible that telomerase may support existing cancer cells. Of course this is only theoretical
Telomerase shortening does not occur the same way in animals as humans making it very difficult to test the viability of telomerase preserving products.
Proven Therapies
To date altering your lifestyle to live longer has been proven to be effective in many parts of the world. Dan Buettner's Blue Zones book explores cultures around the world that live longer on average by 10-20 years than that of the majority of westerners. Places like Ikaria Greece, the Swedish town of Kungsholmen, Okinawa, Japan and Nicoya in Costa Rica show that maintaining active social networks, pursuing leisure activities, avoiding smoking, getting regular exercise, eating lots of vegetables and fruit, a little fish and whole grains and a little red wine is their secret to longevity. Some scientists have speculated that these people are increasing telomerase activity already naturally.
Further Reading
Dan Buettner's
The Blue Zones
Workbook for the Blue Zones
Thrive: Finding Happiness the Blue Zones Way